The Ubiquitin E3 Ligase PUB17 Positively Regulates Immunity by Targeting a Negative Regulator, KH17, for Degradation.
Identifieur interne : 000028 ( Main/Exploration ); précédent : 000027; suivant : 000029The Ubiquitin E3 Ligase PUB17 Positively Regulates Immunity by Targeting a Negative Regulator, KH17, for Degradation.
Auteurs : Hazel Mclellan [Royaume-Uni] ; Kai Chen [République populaire de Chine] ; Qin He [Royaume-Uni, République populaire de Chine] ; Xintong Wu [République populaire de Chine] ; Petra C. Boevink [Royaume-Uni] ; Zhendong Tian [République populaire de Chine] ; Paul R J. Birch [Royaume-Uni]Source :
- Plant communications [ 2590-3462 ] ; 2020.
Abstract
Ubiquitination is a post-translational modification that regulates many processes in plants. Several ubiquitin E3 ligases act as either positive or negative regulators of immunity by promoting the degradation of different substrates. StPUB17 is an E3 ligase that has previously been shown to positively regulate immunity to bacteria, fungi and oomycetes, including the late blight pathogen Phytophthora infestans. Silencing of StPUB17 promotes pathogen colonization and attenuates Cf4/avr4 cell death. Using yeast-2-hybrid and co-immunoprecipitation we identified the putative K-homology (KH) RNA-binding protein (RBP), StKH17, as a candidate substrate for degradation by StPUB17. StKH17 acts as a negative regulator of immunity that promotes P. infestans infection and suppresses specific immune pathways. A KH RBP domain mutant of StKH17 (StKH17GDDG) is no longer able to negatively regulate immunity, indicating that RNA binding is likely required for StKH17 function. As StPUB17 is a known target of the ubiquitin E3 ligase, StPOB1, we reveal an additional step in an E3 ligase regulatory cascade that controls plant defense.
DOI: 10.1016/j.xplc.2020.100020
PubMed: 32715295
PubMed Central: PMC7371183
Affiliations:
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xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA</wicri:regionArea><wicri:noRegion>Dundee DD2 5DA</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Kai" sort="Chen, Kai" uniqKey="Chen K" first="Kai" last="Chen">Kai Chen</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="He, Qin" sort="He, Qin" uniqKey="He Q" first="Qin" last="He">Qin He</name><affiliation wicri:level="1"><nlm:affiliation>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA</wicri:regionArea><wicri:noRegion>Dundee DD2 5DA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Xintong" sort="Wu, Xintong" uniqKey="Wu X" first="Xintong" last="Wu">Xintong Wu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="Boevink, Petra C" sort="Boevink, Petra C" uniqKey="Boevink P" first="Petra C" last="Boevink">Petra C. Boevink</name><affiliation wicri:level="1"><nlm:affiliation>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA</wicri:regionArea><wicri:noRegion>Dundee DD2 5DA</wicri:noRegion></affiliation></author><author><name sortKey="Tian, Zhendong" sort="Tian, Zhendong" uniqKey="Tian Z" first="Zhendong" last="Tian">Zhendong Tian</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070</wicri:regionArea><wicri:noRegion>Hubei 430070</wicri:noRegion></affiliation></author><author><name sortKey="Birch, Paul R J" sort="Birch, Paul R J" uniqKey="Birch P" first="Paul R J" last="Birch">Paul R J. Birch</name><affiliation wicri:level="1"><nlm:affiliation>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA</wicri:regionArea><wicri:noRegion>Dundee DD2 5DA</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA</wicri:regionArea><wicri:noRegion>Dundee DD2 5DA</wicri:noRegion></affiliation></author></analytic><series><title level="j">Plant communications</title><idno type="eISSN">2590-3462</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ubiquitination is a post-translational modification that regulates many processes in plants. Several ubiquitin E3 ligases act as either positive or negative regulators of immunity by promoting the degradation of different substrates. StPUB17 is an E3 ligase that has previously been shown to positively regulate immunity to bacteria, fungi and oomycetes, including the late blight pathogen <i>Phytophthora infestans</i>. Silencing of <i>StPUB17</i> promotes pathogen colonization and attenuates Cf4/avr4 cell death. Using yeast-2-hybrid and co-immunoprecipitation we identified the putative K-homology (KH) RNA-binding protein (RBP), StKH17, as a candidate substrate for degradation by StPUB17. StKH17 acts as a negative regulator of immunity that promotes <i>P. infestans</i> infection and suppresses specific immune pathways. A KH RBP domain mutant of StKH17 (StKH17<sup>GDDG</sup>) is no longer able to negatively regulate immunity, indicating that RNA binding is likely required for StKH17 function. As StPUB17 is a known target of the ubiquitin E3 ligase, StPOB1, we reveal an additional step in an E3 ligase regulatory cascade that controls plant defense.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32715295</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2590-3462</ISSN><JournalIssue CitedMedium="Internet"><Volume>1</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Jul</Month><Day>13</Day></PubDate></JournalIssue><Title>Plant communications</Title><ISOAbbreviation>Plant Commun</ISOAbbreviation></Journal><ArticleTitle>The Ubiquitin E3 Ligase PUB17 Positively Regulates Immunity by Targeting a Negative Regulator, KH17, for Degradation.</ArticleTitle><Pagination><MedlinePgn>100020</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.xplc.2020.100020</ELocationID><Abstract><AbstractText>Ubiquitination is a post-translational modification that regulates many processes in plants. Several ubiquitin E3 ligases act as either positive or negative regulators of immunity by promoting the degradation of different substrates. StPUB17 is an E3 ligase that has previously been shown to positively regulate immunity to bacteria, fungi and oomycetes, including the late blight pathogen <i>Phytophthora infestans</i>. Silencing of <i>StPUB17</i> promotes pathogen colonization and attenuates Cf4/avr4 cell death. Using yeast-2-hybrid and co-immunoprecipitation we identified the putative K-homology (KH) RNA-binding protein (RBP), StKH17, as a candidate substrate for degradation by StPUB17. StKH17 acts as a negative regulator of immunity that promotes <i>P. infestans</i> infection and suppresses specific immune pathways. A KH RBP domain mutant of StKH17 (StKH17<sup>GDDG</sup>) is no longer able to negatively regulate immunity, indicating that RNA binding is likely required for StKH17 function. As StPUB17 is a known target of the ubiquitin E3 ligase, StPOB1, we reveal an additional step in an E3 ligase regulatory cascade that controls plant defense.</AbstractText><CopyrightInformation>© 2020 The Authors.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McLellan</LastName><ForeName>Hazel</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Kai</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Qin</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xintong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boevink</LastName><ForeName>Petra C</ForeName><Initials>PC</Initials><AffiliationInfo><Affiliation>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tian</LastName><ForeName>Zhendong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Horticultural Plant Biology (HZAU), Ministry of Education, Key Laboratory of Potato Biology and Biotechnology (HZAU), Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, Hubei 430070, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birch</LastName><ForeName>Paul R J</ForeName><Initials>PRJ</Initials><AffiliationInfo><Affiliation>Division of Plant Science, School of Life Science, University of Dundee (at JHI), Invergowrie, Dundee DD2 5DA, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cell and Molecular Science, James Hutton Institute, Invergowrie, Dundee DD2 5DA, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Plant Commun</MedlineTA><NlmUniqueID>101769147</NlmUniqueID><ISSNLinking>2590-3462</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">E3 ligase</Keyword><Keyword MajorTopicYN="N">KH RNA-binding protein</Keyword><Keyword MajorTopicYN="N">late blight</Keyword><Keyword MajorTopicYN="N">oomycete</Keyword><Keyword MajorTopicYN="N">plant disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>08</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>01</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>7</Month><Day>28</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32715295</ArticleId><ArticleId IdType="doi">10.1016/j.xplc.2020.100020</ArticleId><ArticleId IdType="pii">S2590-3462(20)30001-8</ArticleId><ArticleId IdType="pii">100020</ArticleId><ArticleId IdType="pmc">PMC7371183</ArticleId></ArticleIdList><pmc-dir>pmcsd</pmc-dir>
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Birch</name><name sortKey="Birch, Paul R J" sort="Birch, Paul R J" uniqKey="Birch P" first="Paul R J" last="Birch">Paul R J. Birch</name><name sortKey="Boevink, Petra C" sort="Boevink, Petra C" uniqKey="Boevink P" first="Petra C" last="Boevink">Petra C. Boevink</name><name sortKey="He, Qin" sort="He, Qin" uniqKey="He Q" first="Qin" last="He">Qin He</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Kai" sort="Chen, Kai" uniqKey="Chen K" first="Kai" last="Chen">Kai Chen</name></noRegion><name sortKey="He, Qin" sort="He, Qin" uniqKey="He Q" first="Qin" last="He">Qin He</name><name sortKey="Tian, Zhendong" sort="Tian, Zhendong" uniqKey="Tian Z" first="Zhendong" last="Tian">Zhendong Tian</name><name sortKey="Wu, Xintong" sort="Wu, Xintong" uniqKey="Wu X" first="Xintong" last="Wu">Xintong Wu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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